Spencer Bliven

Thoughts and Research

Mass Spectrometry Review of PTMs

I’ve been taking CHEM 283 with Dr. Majid Ghassemian. It’s a practical lab course on mass spectrometry. For the final, we had to analyze a sample of alpha-casein (the main protein in cow milk) and present a report on some aspect of the results. I chose to focus on methods for identifying post-translational modifications using mass spec, as exemplified by the programs MASCOT, InsPecT, and MS-Alignment.

Self-analysis: Good journal-club-type discussion of the algorithms. The data is largely irrelevant to my point (due to lack of InsPecT training on QStar), but I had to fit in my experimental results somehow.

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